Trazodona infarmed

trazodona infarmed

What do you need to know about trazodone?

Trazodone 1 Trazodone is an antidepressant medicine. 2 Important Information. You should not use trazodone if you are allergic to it,... 3 Before taking this medicine. You should not use trazodone if you are allergic to it. 4 Take the medicine as soon as you can,... 5 Trazodone side effects. Get emergency medical help...

What should I do if I take too much trazodone?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of trazodone can be fatal when it is taken with alcohol, barbiturates such as phenobarbital, or sedatives such as diazepam (Valium). Overdose symptoms may include extreme drowsiness, vomiting,...

How is trazodone metabolized and eliminated from the body?

Activated charcoal and forced diuresis may be useful in facilitating elimination of the drug; gastric lavage has been shown to not be useful unless done during the first hour after intake. Trazodone is metabolized by several liver enzymes, including CYP3A4, CYP2D6, and CYP1A2.

Is trazodone an anticholinergic?

Also, trazodone showed anxiolytic properties, low cardiotoxicity, and relatively mild side effects. Because trazodone has minimal anticholinergic activity, it was especially welcomed as a treatment for geriatric patients with depression when it first became available.

Does trazodone make you high?

Trazodone is sold under brand names like Oleptro and Desyrel. While trazodone is not a commonly abused drug, some people use the drug recreationally. Trazodone does not produce a euphoric high, but it can have sedative effects and produce cognitive impairment.

Does trazodone cause a false positive on a drug test?

Trazodone has been known to produce false-positive results for amphetamine drugs. This means that anyone taking trazodone could get a false-positive for amphetamines on a drug test. There are other situations, such as pre-employment drug screenings, when you might not want testers to know that you are taking antidepressants.

How Much Trazodone to Overdose? Doctors often recommenda daily dose of 150 mg of trazodone for depressiontreatment. This amount can be increased to upward of 600 mg if necessary. Much lower doses are used to treat insomnia.

What is the best time of day to take trazodone?

Because trazodone is used at high doses in depression, it is important not to stop the drug cold turkey. Instead, if you are stopping trazodone, your dose should be slowly tapered over two to four weeksto avoid withdrawal symptoms. You Might Be Interested In: Depression Hotlines How Long Does Depression Last?

How does metabolic trazodone work?

Metabolism is a wide range of processes within the body that either builds up or breaks down different substances. Trazodone is metabolized by the liver and is changed into an active metabolite. An active metabolite just refers to the active form of the drug after it has been metabolized, this is what makes it work!

What percentage of trazodone is excreted from the body?

Due to the fact that Trazodone is extensively metabolized in the liver, less than 1% of a dose is excreted as the drug “unchanged.” Up to 75% of an oral dose is excreted by the kidneys in the form of various metabolites, with OTPA (oxotriazolopyridinpropionic acid) accounting for ~20%.

What is the half life of trazodone mCPP?

Trazodone forms a primary metabolite known as “m-chlorophenylpiperazine” (mCPP) which has a half-life of 2.4 to 6.8 hours. However, other metabolites of Trazodone have been reported to carry an elimination half-life of up to 13 hours.

How long do trazodone metabolites stay in hair?

The Trazodone metabolites get stored in fast-growing cells, such as hair. Hair tests can detect drugs for an extended period of time, including antidepressants. They can detect Trazodone metabolites in hair for at least 90 days. How Long Does Trazodone Stay in Your Blood?

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